Nothing is known about Orthopox before the invasion of Earth, except that he was able to conquer quite a few worlds for the Empire, and that he and Crypto have been companions all their lives, being like a father figure toward the Furon soldier. His incarnation as Orthopox 14 has shrunken his head and replaced his original, meek body with a much stronger, monkey body. Pox's own head is quite big, marking him as a very high-ranking and intelligent Furon. Pox is mostly identified by his lab coat, four large horns protruding from his head, and the two metal links used to hold his head up a trait not seen in any other Furon. These traits were elevated after Orthopox lost his own body, angering him to no end. Being a high-ranking Furon Commander, Orthopox is quite bossy and narcissistic. Pox also shows a bit of a sadistic streak and, much like Crypto, has little regard for life, unless they prove to be strategically valuable. Its clear Pox is a businessman, having started his own successful fast-food franchise and running Crypto's casino.
While Orthopox is indeed capable of inventing new weaponry and upgrades, he usually does it at a price.
Despite being gifted with a large brain, Pox's own schemes and plans lack a bit of foresight, not to mention appealing to his ego ensures remaining on Pox's good side. Orthopox is known for being both extremely intelligent and extremely prideful, in other words, Orthopox is basically a mad scientist. Orthopox is Cryptosporidium's mission officer, who gives him his assignments.